UCR Spinoff Basilard BioTech Featured in Reputed Journal ‘Nature’ for its Gene-Delivery Innovation

By: Sharjeel Sohaib


Jul 14, 2022


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Basilard BioTech was featured in Nature Journal due to its remarkable use of nanotechnology. The University of California (UC) Riverside spin-off, Basilard BioTech (basilardbiotech.com), views its “deterministic mechanoporation” technology as the pivotal point of its gene-delivery innovation. In this method, each cell is “poked” by a nanomechanical element (a silicon nanoneedle) only once, not randomly.

How Nanotechnology Will Change Our Lives

The era of nanomedicine is just beginning. Soon, nanoparticles and nanodevices will serve as precise medication delivery systems, cancer treatment equipment, or miniature surgical instruments.

Check out this video to know four ways in which nanotechnology can change our lives:

What are Nanoneedles?

Nanoneedles, which are vertical arrays of high-aspect-ratio nanomaterials, have become one of these nanotechnologies and have shown to be a straightforward, controlled, and effective technique for effectively accessing cells with little disturbance. 

Nanoneedles are quickly becoming viable alternatives for sensing and provide a way to revolutionize gene and cell therapy. The transformational potential of nanoneedles is still being realized. The Journal of Nature examines the rapidly developing innovations and robust commercial operations of nanoneedle technology from top academics, businesspeople, and venture investors; all are significant contributors to developing a workable nanoneedle technology for medical applications.

Why are Nanoneedles Becoming an Important Part of Science?

Access and transportation inside the cramped, dynamic environment of the cell are tightly controlled. Standard intracellular delivery and sensing techniques severely disrupt cell function, which limits their physiological applicability. 

The ingenuity of nanoneedles lies in their ability to enter various cell types repeatedly while causing minimum and temporary disturbance, allowing for the effective administration of sophisticated therapies (nano injection) and non-destructive cell state sampling (nano biopsy). The commercial interest in nanoneedles has increased due to their success in the lab, and start-ups seeking to create and use nanoneedle goods and services have seized this opportunity.

How Basilard BioTech is Utilizing Nanotechnology?

The University of California (UC) Riverside spin-off Basilard BioTech (basilardbiotech.com) views its “deterministic mechanoporation” technology as the pivotal component of its gene-delivery innovation. In this method, each cell is “poked” by a nanomechanical element (a silicon nanoneedle) only once and not randomly. The consistent, dependable, and less-disturbing delivery of genetic material is promised by this repeatable mechanical portion by a single needle on a single cell in the same area, which is an essential objective for CAR T-cell technology. The co-founders of Professor Masaru Rao and Mr. Brynely Lee believe that their technique will significantly change cellular immunotherapies, particularly CAR T-cell treatment.

A Glimpse of Basilard BioTecg Nanomechanical Gene Delivery

Basilard BioTech – Transforming the Cell-Based Therapies

Startempire Wire also reported that CellettoTM, the company’s innovative gene delivery technology platform, was unveiled in 2019. This unique technique for nanomechanical gene delivery has the potential to overcome the present limits of viral and non-viral gene delivery, paving the way for more scalable and cost-effective cell and gene therapy manufacturing.

We Covered this in our Weekly Wire Roundup

Wrap Up

The approach developed by Basilard BioTech is exceptional for its singular ability to precisely and securely produce a single pore in both the plasma and nuclear membranes of every cell in a large population. This is effective because it helps intranuclear administration via direct injection, high cellular viability and delivery efficiency, and uniform treatment of all cells.

Check out the complete article about nanotechnology at: https://www.nature.com/articles/s41565-022-01158-5

Related: We have covered the news of how the Wet Lab Incubator will help the Biotech startup ecosystem in the Inland Empire. Read more about that


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